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Chlamydiae and Chlamydial Infections
Chlamydiae are a group of obligate intracellular microorganisms with a homogeneous group-specific antigenic structure, and a unique mode of development. The infections caused by them are unprecedented and wide-spread throughout the world, including a broad range of hosts among domestic and animal species and humans, and a variety of clinical manifestations. The uniqueness of chlamydia pathology consists mainly in the fact that the agents of the individual diseases are so close in their biological properties that they are represented only by the single genus Chlamydia, which includes all currently recognized species.

Although chlamydiae and chlamydial infections were discovered a long time ago, they are still under-researched and relatively unknown to broad circles of microbiologists, virologists, epidemiologists and clinicians. A number of issues relating to molecular biology, pathogenesis, mechanisms of Chlamydia development and their interactions with cells, as well as their genetic conditioning and regulation, remain unclear. The same is true for ambiguities, problems and contradictions related to epidemiology, diagnostic approaches, immunity and vaccines. Based on scientific facts and the analysis of literature, and the experience of the author, Chlamydiae and Chlamydial Infections attempts to shed light on the cited problems, in terms of modern microbiology, cell biology and molecular biology. The scientific topics discussed include:

- Biological, morphological and antigenic properties of Chlamydia spp
- Genes, genomic structure and genetic regulations
- Conventional diagnostic methods and examinations
- Detection and differentiation of Chlamydia organisms by DNA detection systems
- Clinical forms and manifestations and drug therapy
- Pathology
- Epidemiological peculiarities of Chlamydia - induced diseases in animals and humans
- Immunity and vaccines.

Table of Contents:

1. Historical Notes
2. Nature of Chlamydia Organisms and Taxonomy
3. Morphology, mode of development, interaction with the cells
4. Genomic structure, Genes, Molecular regulation of the development of Chlamydiae
5. Isolation and cultivation of Chlamydia
6. Virulence and pathogenicity
7. Chlamydial antigens and antigenic analysis
8. Immunity and antibodies
9. Serology
10. Detection and differentiation of Chlamydia microorganisms by DNA detection systems
11. Clinical Picture
12. Pathology
13. Epidemiology
14. Vaccines for Chlamydia-induced diseases
Keyword Index
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Tourism and Animal Welfare
This book addresses the issue of animal welfare within the tourism experience. The first part explores the meaning of animal welfare and its relation to ethics, animal rights, and human obligations to animals. It also explores the nature and diversity of the position and role of animals within tourism.

Part Two builds upon concepts and ideas and reflects the views of a variety of animal welfare organizations and individual leaders, tourism industry organizations, tourism operators, and academic experts, about the nature of the tourism industry, the welfare needs of animals, and whether or how the two can co-exist. The case studies and opinion pieces that constitute this section encompass differing perspectives on animal welfare and tourism.

With contributions from Jane Goodall, Founder - the Jane Goodall Institute and UN Messenger of Peace.

Table of Contents:
1. Introduction

Part 1. A conceptual and historical foundation
2. Animal sentience, ethics, and welfare
3. The position of animals in tourism
4. Animal welfare and tourism: are the aims mutually exclusive or potentially inclusive?

Part 2. Tales from the front line: Animal welfare organisations and animal tourism providers
5. Public Aquariums in the 21st Century – what’s next, before it’s too late?
6. A tale of two zoos: Tourism and zoos in the 21st century
7. A Comparison of tourism and food-provisioning among wild bottlenose dolphins at Monkey Mia and Bunbury, Australia
8. The tourism industry and shark welfare
9. Tourism, wildlife conservation and animal welfare
10. Managing tourism’s animal footprint
11. Elephants and tourism
12. Lessons from Winnie-the-Pooh: How responsible bear tourism can teach us respect and compassion, and benefit bears
13. Donkeys and mules and tourism
14. Cats and dogs international
15. Animal welfare – driving improvements in tourism attractions
16. Animal welfare and tourism: the threat to endangered species
17. Sport hunting tourism
18. Ethical hunting

Part 3: The future and moving forward together
19. The future and moving forward together
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Energy Balance and Obesity
Understanding the relationship between energy balance and obesity is essential to develop effective prevention programs and policies.

The International Agency for Research on Cancer convened a Working Group of world-leading experts in December 2015 to review the evidence regarding energy balance and obesity, with a focus on low- and middle-income countries, and to consider the following scientific questions:

(i) Are the drivers of the obesity epidemic related only to energy excess and/or do specific foods or nutrients play a major role in this epidemic?
(ii) What are the factors that modulate these associations?
(iii) Which types of data and/or studies will further improve our understanding?

This book provides summaries of the evidence from the literature as well as the Working Group's conclusions and recommendations to tackle the global epidemic of obesity.

Table of Contents:
Foreword and Acknowledgements
Working Group members
Executive summary

1. Global trends in overweight and obesity
2. The double burden of malnutrition in low- and middle-income countries
3. Can energy intake and expenditure (energy balance) be measured accurately in epidemiological studies? Is this important?
4. How are components of dietary intake, dietary composition, foods, and nutrients related to obesity and weight gain?
5. How are overall energy intake and expenditure related to obesity?
6. Physical activity, sedentary behaviour, and obesity
7. What existing epidemiological data could serve to better understand the relationship of energy intake and expenditure to obesity and the obesity epidemic?
8. Cultural determinants of obesity in low- and middle-income countries in the Eastern Mediterranean Region
9. Potential mechanisms in childhood obesity: causes and prevention
10. The interplay of genes, lifestyle, and obesity
11. The gut microbiota and obesity
12. Molecular and metabolic mechanisms underlying the obesity-cancer link
13. What steps should be recommended and implemented to prevent and control the obesity epidemic?
14. Which new data are needed to explore the relationships of diet and dietary patterns to obesity and weight gain?
Disclosures of interests
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Bovine Tuberculosis
This book is contemporary, topical and global in its approach, and provides an essential, comprehensive treatise on bovine tuberculosis and the bacterium that causes it, Mycobacterium bovis. Bovine tuberculosis remains a major cause of economic loss in cattle industries worldwide, exacerbated in some countries by the presence of a substantial wildlife reservoir. It is a major zoonosis, causing human infection through consumption of unpasteurized milk or by close contact with infected animals.

Following a systematic approach, expert international authors cover epidemiology and the global situation; microbial virulence and pathogenesis; host responses to the pathogen; and diagnosis and control of the disease.

Aimed at researchers and practicing veterinarians, this book is essential for those needing comprehensive information on the pathogen and disease, and offers a summary of key information learned from human tuberculosis research. It will be useful to those studying the infection and for those responsible for controlling the disease.

Table of Contents:
1: Bovine tuberculosis: worldwide picture
2: Mycobacterium bovis as the causal agent of human tuberculosis: Public Health Implications
3: Economics of bovine tuberculosis: a One Health issue
4: The Epidemiology of Mycobacterium bovis Infection in Cattle
5: Mycobacterium bovis molecular typing and surveillance
6: Bovine Tuberculosis in Other Domestic Species
7: Role of wildlife in the epidemiology of Mycobacterium bovis
8: Molecular virulence mechanisms of Mycobacterium bovis
9: The pathology and pathogenesis of Mycobacterium bovis infection
10: Innate immune response in bovine tuberculosis
11: Adaptive immunity
12: Immunological Diagnosis
13: Biomarkers in the Diagnosis of Mycobacterium tuberculosis Complex Infections
14: Vaccination of domestic and wild animals against tuberculosis
15: Managing Bovine Tuberculosis; Successes and Issues
16: Perspectives on global bovine TB control
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Veterinary Clinical Skills Manual
Down-to-earth and intensely practical, this book and video package describes in a step-by-step way the essential clinical skills that veterinary students need to acquire before they face clinical situations in the real world of the busy veterinary clinic.

- Contains step-by-step illustrations and photographs, and videos of clinical procedures which can be viewed on your desktop, smartphone or tablet
- Covers the essential key skills that you need to know, with more available online
- Details a whole range of skills from: surgical, anaesthesia, laboratory, through to everyday essential skills and diagnostic skills in both farm and companion animals
- The use of simulators in learning key skills is covered in depth
- Get advice on preparing for OSCEs and practical exams

This book is the go-to manual for an essential grounding in key veterinary clinical skills for all students and educators of veterinary medicine and animal husbandry.

Table of Contents:
Section 1: Introduction
Foreword—Prof David Church
Editor’s Note—Nichola Coombes & Dr Ayona Silva-Fletcher
How to use this book—Nichola Coombes
Developing veterinary clinical skills, the pedagogy—Prof Stephen May
2.The modern outcome-based curriculum and the role of clinical skills laboratory—Associate Prof. Ayona Silva-Fletcher
3.The Variety of Clinical Skills Centre Models relevant to location—Nichola Coombes, Ayona Silva-Fletcher, Julie Williamson, Stacy Anderson, B. Otgontugs, N. Odontsetseg, Aruna Amarasinghe, M.L.A.N.R Deepani, Catherine. J. Wager and Desiree Karlsson

Section 2: Surgical Theatre Skills
Section editor – Fiona Brown
4.Theatre Practice—Fiona Brown
5.Surgical Instruments—Alison Young
6.The Fundamentals of Suturing—Nicola Kulendra

Section 3: Anaesthesia
Section editor – Fiona Brown
7.The Anaesthetic machine—Dr Christopher Seymour and Fiona Brown
8a. Breathing Systems—Dr Christopher Seymour and Fiona Brown
8b. Intubation and Monitoring Anaesthesia—Caroline Hoy, Dr Christopher Seymour and Fiona

Section 4: Principles and good practice in the Laboratory
Section editor – Alison Langridge
9a. Introduction to Laboratory—Kate English and Alison Langridge
9b. Principles in sample collection—Kate English and Alison Langridge
10. Using a microscope and preparing samples—Kate English and Alison Langridge
11. Urine and Faecal Analysis—Kate English and Alison Langridge

Section 5: General Clinical Skills
Section editor – Alison Langridge
12. Physical examination, fluid therapy, tube and drain management—Karen Humm
13. Principles of small animal bandaging—Alison Langridge
14. Pharmacy—Hilary Orpet

Section 6: Patient Handling & Diagnostics
Section Editor – Isobel Vincent
15. General principles of animal handling—Dr Isobel Vincent
16. Diagnostic Imaging—Dr Pete Mantis and Victoria Watts
17. Radiography of the Equine Tarsus—Prof Renate Weller

Section 7: Large animal skills
Section Editor – Dr Isobel Vincent,
18. Udder Health—John Fishwick and Dr Isobel Vincent
19. Equine procedures—Dr Imogen Johns
20. Equine Shoe Removal—Prof Renate Weller

Section 8: Assessment in Clinical Skills
Section Editor – Dr Matthew Pead
21. Practical Assessments – the basis of scoring performance in assessments in a simulated
Environment—Dr Matthew Pead
22. OSCE’s - the practicalities in the CSC environment—Nichola Coombes

Section 9: Moving Forward
23. Model design, creation, validation & use—Rachel Lumbis
24. Simulators in a simulated environment, variation and use—Dr Tierney Kinnison
25. Transition between the skills lab and the real world—Desiree Janine Herrick

Conclusion—Dr Ayona Silva-Fletcher and Nichola Coombes
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Proceedings of the 11th International Veterinary Behaviour Meeting
This book contains the proceedings from the 11th International Veterinary Behaviour Meeting. Keynote Presentations include 'Use of Psychopharmacology to Reduce Anxiety and Fear in Dogs and Cats: A Practical Approach' by Barbara L. Sherman, 'A Multimodal Approach to Resolving Tension Between Cats in the Same Household: A Practical Approach' by Sarah E. Heath, 'The Importance of the Welfare of Research Animals to Maximise the Quality of Behavioural Research: Do We Measure True Behaviours?' by Patrick Pageat and 'Making Animal Welfare Sustainable - Human Behaviour Change for Animal Behaviour: The Human Element' by Jo White and Suzanne Rogers.

Table of Contents:
Section: Thursday September 14th, 2017
1. Predicting Aggressive Behaviour: Which Factors Influence Biting and What is the Use of Temperament Tests?
2. No Better Than Flipping a Coin: Reconsidering Canine Behaviour Evaluations in Animal Shelters
3. Having Bitten is No One-way Ticket for Dogs: Rehabilitation Possibilities and Principles
4. Evaluation, Management and Welfare of Aggressive Shelter Dogs
5. Keynote Presentation: Use of Psychopharmacology to Reduce Anxiety and Fear in Dogs and Cats: A Practical Approach
6. Preventing Travel Anxiety Using Dexmedetomidine Hydrochloride Oromucosal Gel
7. Oromucosal Dexmedetomidine Gel for Alleviation of Fear and Anxiety in Dogs During Minor Veterinary or Husbandry Procedures
8. Avalanche Dogs Can Locate ‘Buried Victims’ by Perceiving the Human Breath Under the Snow
9. Responses of Anxious Dogs to a Simple Behaviour Modification Protocol While Waiting in a Veterinary Hospital
10. Link Between Chronic Gastric Diseases and Anxiety in Dogs
11. Interaction of Health and Behaviour Problems in Dogs
12. Keynote Presentation: A Multimodal Approach to Resolving Tension Between Cats in the Same Household: A Practical Approach
13. Effect of a Synthetic Feline Pheromone for Managing Unwanted Scratching in Domestic Cats
14. Relationship Among Cat–Owner Bond, Cat Behaviour Problems and Cat Environment Conditions: A Study With 1553 Spanish Cat Owners

Section: Friday September 15th, 2017
15. Keynote Presentation: The Importance of the Welfare of Research Animal to Maximise the Quality of Behavioural Research: Do We Measure True Behaviours?
16. Keynote Presentation: Human Behaviour Change for Animals
17. Impact of Exploratory Material and Stocking Density on Tail and Ear Biting in Suckling and Weaning Piglets
18. Ontogeny of Selected Behaviours in Piglets of Slovak Large White Improved Swine Breed
19. Access to Chewable Materials Increases Piglet Activity During Lactation
20. Hypothermia Triggers Depression-like Behaviour in Mice Forced Swimming Test
21. Effects of Maternal Depression and Antidepressant Therapy on the Neurobehavioural Development of Rat Offspring
22. From Neuronal Activity to Behaviour: Understanding Neuronal Correlates of Sensory Discrimination
23. Environmental Control of Crib-biting in a Horse
24. Do Different Types of Food Provoke Different Levels of Enjoyment in Dogs?
25. Survey of Shock Collar Use in France: Providing Practical Results for Regulatory Guidelines Development
26. ‘Long-stay’ Dogs in Shelters: Studying Factors Related to Adoptability of Difficult to Adopt Dogs in Catalonia
27. Compulsive Self-licking and Self-biting in Dogs with Paraesthesia: Two Cases
28. Use of Huperzine A in Three Canine Cases in Australia
29. Mirtazapine as a Potential Drug to Treat Social Fears in Dogs: Five Case Examples
30. Polyuria and Polydipsia Associated with Hypersensitivity–Hyperactivity Syndrome (Attention Deficit Hyperactivity Disorder) in a Dog: A Case Report of a Male French Shepherd Dog (Beauceron)
31. Two Approaches to Managing Separation Anxiety
32. The Effects of a Nutritional Supplement (Solliquin) in Reducing Fear and Anxiety in a Laboratory Model of Thunder-induced Fear and Anxiety
33. Observing the Results of Reducing the Stress of the Dogs During Training by the Help of Dog-appeasing Pheromone on Learning and Problem-solving Behaviours
34. Evaluation of the Association Between Attendance at Veterinary Hospital-based Puppy Socialisation Classes and Long-term Retention in the Home

Section: Saturday September 16th, 2017
35. Effects of Olfactory Stimulation with Essential Oils in Animals: A Review
36. Olfactory Enrichment in Dogs: Possible New Applications
37. Hair Cortisol in Cats as a Measure of Chronic Stress: A Pilot Study Under Controlled Conditions
38. Cortisol Content in Hair Measured by Liquid Chromatography–Tandem Mass Spectrometry: A Non-invasive Marker of Chronic Stress in Companion Animals
39. Association Between Catecholaminergic Genes and Impulsivity in Dogs
40. Do Assistance Dogs Show Work Overload? Canine Blood Prolactin as a Clinical Parameter to Detect a Chronic Stress-related Response
41. Efficacy of a Therapeutic Diet on Dogs with Signs of Cognitive Dysfunction Syndrome
42. Social Behaviour and Bonding in Aged Dogs: A Multimodal Assessment Approach
43. Olfactory Stem Cell Therapy in Canine Age-related Disorders Treatment: A Controlled Study
44. Neophilia in Successfully Ageing Dogs: Preliminary Results
45. The Attachment Bond to People in Domestic Dogs: Does it Exist Already in Puppies?
46. Living with and Loving a Pet with Behaviour Problems: The Impact on Caregivers
47. The Personality of Dogs and Cats Living in the Same Household: A Multivariate Model Study
48. A Comparison of Attitudes and Coping Strategies of Small Animal Veterinarians Toward Behaviour Problems of Companion Dogs in Israel and Brazil
49. The Latin Owner: Profiles, Perceptions and Attitudes of Italian Cat and Dog Owners Towards their Pet
50. Coping Strategies in Dogs with Impaired Social Functioning Towards Humans
51. Predictors of Gaze-directed Attention in Dogs
52. The Effect of Paw Preference on Problem-solving Ability in Cats: Preliminary Results
53. The Impact of Transportation-related Anxiety on the Quality of Pre-anaesthesia in Cats: A Preliminary Study

Section: Poster Presentations
54. Playful Activities Post-learning Improve Retraining Performance a Year Later in Labrador Retriever Dogs (Canis lupus familiaris)
55. Adoption Preference Factors for Dogs in a Public Shelter in the Province of Palermo (Southern Italy) and Comparison with Adoption Rates of a Shelter in Northern Italy
56. Relation Between the Owner’s Psychological Well-being and Pets’ Behavioural Problems: A Portuguese Survey
57. The Association of Multiple Clinical Signs to Determine if a Cat Displays Either Urine Marking or Latrine Behaviour
58. Mirror Reflection or Real Image: Does Past Mirror Experience Influence a Dog’s Use of a Mirror?
59. Association Between Puppy Classes and Adult Behaviour of the Dog
60. The Importance of Pain as a Differential Diagnosis During a Behaviour Consultation
61. Canine Electroencephalograph Transients in the Sigma Range Relate to Memory
62. Noise Sensitivities in Dogs: An Exploration of Signs in Dogs With and Without Musculoskeletal Pain
63. Evaluation of Urine Cortisol:Creatinine Ratio in Dogs with Separation Anxiety
64. Effects of Providing Two Kinds of Doghouses in Different Sized Pens on the Behaviour of Shelter Dogs
65. Circadian Distribution and Characterisation of Social Behaviour in a Group of Domestic Donkeys (Equus asinus)
66. Effect of Meal Composition on Tryptophan:Large Neutral Amino Acids Ratio in Dog
67. Differences in Management of Dogs and Cats Living in the Same Household
68. Acupuncture Influence on Reduction of Stress Signs in Kennelled Dogs
69. Serum Leptin and Ghrelin Levels and their Relationship with Serum Cortisol, Thyroid Hormones, Lipids, Homocysteine and Folic Acid in Dogs with Compulsive Tail Chasing
70. A Social Entrepreneurship Project on Animal Welfare: ‘Pretty Paws’ Board Game
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Parasites and Pets
A Veterinary Nursing Guide
This book is designed specifically for veterinary nurses and veterinary nursing students, and adopts an inquiry-based approach to assist veterinary nurses in gaining the essential knowledge and practical understanding necessary to excel in supporting veterinary surgeons to achieve an optimal management of parasitic diseases of dogs and cats.

Supported by figures and ending with learning outcomes, each chapter includes a number of questions and answers about a major group of parasites. Readers can also identify their own abilities and areas for development by completing the end-of-chapter self-assessment questions, answers to which can be found at the back of the book. The questions are designed to encourage veterinary nurses to question their practice, rationales, and the evidence base of parasitology care delivery they provide to the patients. By completing all chapters and associated exercises within this book, the readers will gain the essential parasitology knowledge and professional skills needed for parasitology practice.

Table of Contents:
1: Introduction to Parasitology
2: Parasites of the Gastrointestinal System
3: Parasites of the Respiratory System
4: Parasites of the Cardiovascular System
5: Parasites of the Skin and Muscles
6: Parasites of the Eye and Nervous System
7: Parasites of the Urogenital System
8: Key Skills for the Veterinary Nurse in Diagnostic Parasitology
9: Parasite Control Clinics
10: Parasite Control and Pet Travel
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Animal Welfare
Updated and revised, this bestselling textbook continues to provide a broad introduction to the key topics in the welfare of animals both large and small, farm and companion, and wild and zoo. It retains all of the popular features of the previous editions and covers key issues such as ethics, animal pain and injury, health and disease, social conditions, and welfare dilemmas and problems. Importantly, it also offers practical advice for welfare assessment and a full section dedicated to the implementation of solutions.

The third edition:

- Contains many more examples of welfare issues in different countries, particularly the implications for smallholders as well as larger scale agriculture
- Covers fish welfare as well as the welfare of amphibians, reptiles, and invertebrates
- Includes concepts of positive emotion and other positive aspects of welfare
- Focuses on animal welfare and sustainability
- Includes an integrated ebook with additional material and videos

With contributions from renowned international experts and a new editorial team, Animal Welfare 3E is an essential resource for students and researchers in animal and veterinary sciences and other disciplines considering the science and practice of animal welfare as well as for practitioners and decision-makers worldwide.

Table of Contents:

Part I: Issues
1. Animal ethics
2. Understanding animal welfare

Part II: Problems
3. Environmental challenge and animal agency
4. Hunger and thirst
5. Pain
6. Fear and other negative emotions
7. Frustration and boredom in impoverished environments

Part III: Assessment
8. Health and disease
9. Behaviour
10. Physiology
11. Preference and motivation research
12. Practical strategies to assess (and improve) welfare

Part IV: Solutions
13. Physical conditions
14. Social conditions
15. Human contact
16. Genetic selection

Part V: Implementation
17. Economics
18. Regulation, enforcement and incentives
19. International issues
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Australia's Dangerous Snakes
Identification, Biology and Envenoming
Australia’s venomous snakes are widely viewed as the world’s most deadly and are regarded with cautious curiosity, fascination, and regrettably, fear. Australia’s Dangerous Snakes examines the biology, natural history, venom properties, and bite treatment of medically-important, venomous marine and terrestrial snakes. It contains comprehensive identification profiles for each species, supported by keys and photographs. In addition to their medical importance, the environmental roles of these snakes and the threats that are causing the decline of many of these reptiles are discussed. Drawing on the authors’ experience in the fields of herpetology, toxinology, and clinical medicine, this book stimulates respect and admiration and dispels fear of Australia’s fascinating snakes.

Australia’s Dangerous Snakes will provide hours of rewarding reading and valuable information for anyone interested in Australia’s unique wildlife and natural history, and it will be an essential reference for herpetologists, toxinologists, physicians, zoo personnel, and private snake collectors.

Table of Contents:
1: Introduction
2: The Relative Danger of Snakes
3: Morphology and General Features of Dangerous Snakes
4: Identification of Dangerous Snakes
5: The Dangerous Snakes Described
6: Conservation of Australia's Dangerous Snakes
7: Production, Actions and Uses of Venoms
8: Snakebite and Envenoming: Risks, Realities and Clinical Management
9: Snakes and People
Appendix: The Pioneers of Venom Production for Australian Antivenoms
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Are We Pushing Animals to Their Biological Limits?
Welfare and Ethical Implications
This new text looks at the welfare problems and philosophical and ethical issues that are caused by changes made to an animal’s telos, behavior, and physiology (both positive and negative) to adapt them for human uses.

These changes may involve selective breeding for production, appearance traits, or competitive advantage in sport; transgenic animals; or the use of pharmaceuticals or hormones to enhance production or performance. Changes may impose duties to care for these animals further and more intensely, or they may make the animal more robust.

Considering a wide range of animals, including farm animals, companion animals, and laboratory animals, the book reviews the ethics and welfare issues of animals which have been adapted for sport, companions, toys, ornaments, food sources, weapons, and a whole host of other human functions. It will spark debate and is essential for all those involved in animal welfare and ethics, including veterinarians, animal scientists, animal welfare scientists, and ethologists.

Table of Contents:
1: Introduction: Use New Genetic Technologies and Animal Breeding Methods Carefully to Avoid Problems
2: Domestication to Dolly and beyond: a brief history of animal modification
3: Good for Whom? Differences between human and animal enhancement
4: Working equids: The welfare of those worked to their limit.
5: Genetics and Other Technologies for Increasing the Productivity of Cattle, Sheep and Pigs: Welfare Implications
6: Technologies for Increasing the Productivity of Poultry: Welfare Implications
7: Selective Breeding, Cloning, and Gene Editing of Dogs and Cats for Appearance and Performance Traits
8: Methods to Increase Fish Production: Welfare and Sustainability Implications
9: Welfare Concerns in Genetically Modified Laboratory Mice and Rats
10: Cloning, Editing and GMOs for Animal Enhancement
11: From Bionic Cat to Superdog – Ethical challenges of advanced prosthetic technology in veterinary medicine
12: Animal Welfare and the Brave New World of Modifying Animals
13: A Duty To The Enhanced, Not A Duty To Enhance: Welfare Responsibilities Associated With Domestication
14: Pressing Animals Beyond their Biological Limits
15: Concluding Animals Pushed to their Limits
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Bovine Pathology
A Text and Color Atlas
Illustrated with over 1,000 color images of the highest quality, Bovine Pathology: A Text and Color Atlas is a comprehensive single resource to identifying diseases in dairy cattle, feedlot cattle, and their calves. With summary text describing key features, the book correlates clinical information with pathology and differential diagnoses.

The text covers naked-eye macroscopic appearance through to microscopic pathology and the immunohistochemistry of infectious agents and tumor markers. Structured by major organ system, the disease entries follow a consistent format and clarity of display. This, combined with an integrated e-book, handy fact sheets, summary boxes and key points, helps aid understanding. Key features include:

- Over 1000 superb color images to illustrate the pathologies
- A thorough review of mainly western hemisphere diseases of cattle covering macroscopic appearance, microscopic appearance, and immunohistochemistry
- Synoptic layout, fact sheets, summary boxes, succinct legends and key bullet points support its use as a field guide or revision aid
- Organized by major organ system which ensures that vital facts can be found quickly
- A unique chapter covering calf-hood diseases

Serving as an essential reference work for veterinary pathologists who perform bovine necropsies, veterinary residents and students, the book is also practical enough for bovine practitioners who need to investigate sudden death losses of cattle on the farm.

Table of Contents:
1: Diseases of Neonates and Calves
2: Diseases of the Nervous System
3: Diseases of the Respiratory System
4: Diseases of the Cardiovascular System
5: Diseases of the Gastrointestinal Tract
6: Diseases of the Hepatobiliary System and Pancreas
7: Diseases of the Urinary System
8: Diseases of the Musculo-Skeletal System
9: Diseases of the Endocrine System
10: Diseases of the Reproductive System
11: Diseases of the Hematopoietic and Hemolymphatic System
12: Diseases of the Integument
13: Diseases of the Claw, Foot Skin and Soft Tissues
14: Diseases of the Udder and Teats
15: Diseases of the Eye and Ears
16: Select Poisonous Plant-Induced Diseases in Cattle
17: Bovine Diseases without Lesions
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The Ethology of Domestic Animals
An Introductory Text
Completely updated, revised, and redesigned in color throughout, this classic text continues to provide a concise introduction to the important fundamentals of animal behavior from genetics, physiology, motivation, learning, and cognition to social and reproductive behavior, abnormal behavior, and human-animal interactions.

This new edition includes:
- Concise, comprehensive coverage of all the fundamentals of animal behavior in companion, farm, and laboratory animals
- The latest evidence-based information on animal behavior and welfare from expert authors and key opinion leaders from around the world
- A revised layout and design with easy to find key information at a glance, making it an ideal rapid revision tool
- New chapters on fur animals with the inclusion of more species and expanded sections on canine behavior

This text remains a highly respected, essential resource for both students and lecturers in animal and veterinary science, animal welfare, zoology and psychology.

Table of Contents:
1. The Study of Animal Behaviour and its Applications, Per Jensen
2. Behaviour Genetics, Evolution and Domestication, Per Jensen
3. Behaviour and Physiology, Anna Valros and Laura Hänninen
4. Motivation and the Organisation of Behaviour, Georgia Mason and Melissa Bateson
5. Learning and Cognition, Michael Mendl and Christine J. Nicol
6. Social and Reproductive Behaviour, Daniel M. Weary and David Fraser
7. Play and Ontogeny of Behaviour, Susan Held
8. Introduction to Animal Personality, Hanne Løvlie
9. Abnormal Behaviour, Stress and Welfare, Linda Keeling and Per Jensen
10. Human-animal Relations, Susanne Waiblinger
11. Behaviour of Domesticated Birds: Chickens, Turkeys and Ducks, Joy Mench
12. Behaviour of Horses, Daniel Mills and Sarah Redgate
13. Behaviour of Cattle, Cassandra B. Tucker
14. Behaviour of Sheep and Goats, Cathy Dwyer
15. Behaviour of Pigs, Marek Špinka
16. Behaviour of Dogs, Deborah L. Wells
17. Behaviour of Cats, John Bradshaw
18. Behaviour of Foxes and Mink Kept for Fur Production, Anne-Lene Hovland, Leena Ahola, Jens Malmkvist
19. Behaviour of Laboratory Mice and Rats, Hanno Würbel, Charlotte Burn and Naomi Latham
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Mindbrain, Psychoanalytic Institutions and Psychoanalysts
A New Metapsychology Consistent with Neuroscience
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Olfaction in Animal Behaviour and Welfare
Evidence-based, yet entirely practical, this important new text builds upon the basics of neuroscience to describe the link between olfaction, animal behavior, and the importance of odors for animal welfare.

Focusing on animals managed by humans, and taking animal behavior as the starting point, the book is written in a straightforward style and features illustrated examples from many different species with in-depth research from acknowledged experts in the area.

From the scientific basis of olfaction and odor perception, the text covers pheromones, odorant learning, and behavioral tests before describing the role of olfaction in, for example, fear, foraging, and reproduction, and olfactory behavior in farm animals, zoo animals, laboratory animals, and companion animals.

Table of Contents:
Section 1
1. The nuts and bolts of olfaction—Nicolas Meunier, French National Instiute for National Research, France & Olivier Rampin, UTL-Essone, France
2. Innateness and learning in olfactory behaviour and odour perception—Birte L Nielsen
3. Pheromones, allelomones and behaviour—Tristram Wyatt, University of Oxford, UK
4. Behavioural tests of olfaction—Markus Fendt, Otto-von-Guericke-Universität Magdeburg, Germany and Raimund Apfelbach, University of Tuebingen, Germany
5. Is there such a thing as a bad smell? —Roland Salesse, INRA, France and Laurent Dormont

Section 2
6. The role of olfaction in feeding and foraging—Marije Oostinder, Norwegian University of Life Science, Norway
7. The role of olfaction in mate selection and reproductive behaviour—Luisa Amo, Spanish National Research Council, Spain
8. The role of olfaction for parental care and offspring survival—Frederic Levy, INRA, France and Raymond Nowak, INRA, France
9. The role of olfaction in disease detection and prevention—Tadeusz Jezierski
10. The role of olfaction in relation to stress and fear—Vincent Bombail, INRA, France
11. The role of olfaction in animal housing and as enrichment—Deborah Wells, Queens University Belfast, UK

Section 3
12. Olfactory behaviour in farm animals—Liesbeth Bolhuis, Wageningen University, Netherlands and Caroline Clouard, Wageningen University, Netherlands
13. Olfactory behaviour in zoo animals—Frank Rosell, Telemark University College, Norway and Roisin Campbell-Palmer
14. Olfactory behaviour in laboratory animals—Anders Ågmo, UIT, Norway
15. Olfactory behaviour in companion animals—Peter Hepper, Queens University Belfast, UK
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Quality Assurance of Pharmaceuticals 2016 [OP]
WHO Guidelines, Good Practices, Related Regulatory Guidance and GXPs Training Materials
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The Twisted Cruelty
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The Animal Trade
Evolution, Ethics and Implications
Trade is an inevitable part of human activity and evolution, but when it involves animals there are important ethical issues that have to be considered. Animal trade is often for economic reasons only, and may be hard to justify ethically. There are significant welfare and environmental costs to animals and human society that must be carefully evaluated before such a trade is sanctioned.

Controversial and thought-provoking, this text focuses on the trade in live and dead animals and animal parts. It examines the facts and figures to quantify the scope of the animal trade, concentrating mainly on farm animals, but also covering captive wildlife and companion animals. The book describes welfare, environmental, economic and cultural issues around this trade, debating important ethical considerations for everyone that uses or is otherwise involved with animals, especially people in animal welfare.

Table of Contents:
1: The history of animal trade

2: Trade policies for animal products

3: Trade wars, sanctions and discrimination

4: Trade in meat

5: Trade in some key animal products: dairy, wool and fur

6: Trade in live farm animals

7: Disease transmission and biodiversity loss through the trade in farm animals

8: Trade in horses, cats and dogs

9: Trade in wildlife and exotic species

10: The future of animal trade
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Development and Rational Use of Standardised MedDRA Queries (SMQs)
Retrieving Adverse Drug Reactions with MedDRA
This publication aims to inform regulatory authorities, scientific institutions, pharmaceutical companies and other organizations or individuals involved in pharmaceutical and other medicinal product development, about the purpose and appropriate use of SMQs in safety surveillance activities.

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Evidence Synthesis and Meta-Analysis for Drug Safety
Report of CIOMS Working Group X
At any point in the drug development process, systematic reviews and meta-analysis can provide important information to guide the future path of the development program and any actions that might be needed in the post-marketing setting. This report gives the rationale for why and when a meta-analysis should be considered, all in the context of regulatory decision-making, and the tasks, data collection, and analyses that need to be carried out to inform those decisions.

There is increasing demand by decision-makers in health care, the bio-pharmaceutical industry, and society at large to have access to the best available evidence on benefits and risks of medicinal products. The best strategy will take an overview of all the evidence and where it is possible and sensible, combine the evidence and summarize the results. For efficacy, the outcomes generally use the same or very similar predefined events for each of the trials to be included. Most regulatory guidance and many Cochrane Collaboration reviews have usually given more attention to assessment of benefits, while issues around combining evidence on harms have not been as well-covered. However, the (inevitably) unplanned nature of the data on safety makes the process more difficult.

Combining evidence on adverse events (AEs), where these were not the focus of the original studies, is more challenging than combining evidence on pre-specified benefits. This focus on AEs represents the main contribution of the current CIOMS X report. The goal of the CIOMS X report is to provide principles on appropriate application of meta-analysis in assessing safety of pharmaceutical products to inform regulatory decision-making. This report is about meta-analysis in this narrow area, but the present report should also provide conceptually helpful points to consider for a wider range of applications, such as vaccines, medical devices, veterinary medicines or even products that are combinations of medicinal products and medical devices.

Although some of the content of this report describes highly technical statistical concepts and methods (in particular Chapter 4), the ambition of the working group has been to make it comprehensible to non-statisticians for its use in clinical epidemiology and regulatory science. To that end, Chapters 3 and 4, which contain the main technical statistical aspects of the appropriate design, analysis and reporting of a meta-analysis of safety data are followed by Chapter 5 with a thought process for evaluating the findings of a meta-analysis and how to communicate these.

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The Clinic of Disability
Psychoanalytical Approaches
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